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commentary on cancer research, information on supplements and treatments, relevant book reviews, links to useful sites and other information that cancer sufferers, their families and friends may find useful. pages home about publications tuesday, 19 june 2018 book review - scam: so-called alternative medicine keywords: homeopathy, alternative medicine title: scam: so-called alternative medicine author: edzard ernst publisher: imprint academic isbn: 978-1845409708 buy us buy uk ‘scam – so-called alternative medicine’, is the follow-up book to ‘ a scientist in wonderland ’, edzard ernst’s very readable memoir. that book, reviewed here previously, ernst told the story of how he came to be the first professor of complementary medicine in the world. it was a post that was greeted enthusiastically by those who were true believers in homeopathy, healing crystals and other forms of ‘alternative medicine’. these true believers assumed that anyone taking on that role would be like minded. unfortunately, ernst decided that he was a scientist first and foremost and that his job meant applying the scientific method to the extraordinary claims made by practitioners. the fall out reached a peak with a very public falling out with prince charles and trouble for ernst from his own university. it’s an interesting story well-told in the first book. in this book ernst is continuing the work that got him into so much trouble. here he outlines how these various alternatives seem to work – their common features, imperviousness to evidence, the magical thinking and conspiracy theories that believers use to counter the lack of evidence. for example, many alternatives claim that much of contemporary medicine also doesn’t stack up and hasn’t been tested vigorously in clinical trial. while there’s a smidgen of truth there, ernst points to the evidence that in conventional practice 80% - 90% is evidence-based (and includes the reference so you can look at the original paper itself). while the book lacks the narrative from the first – after all that was a memoir – it does run over some of the elements of his own experience in battling with prince charles. it’s a book that is informed by long experience talking to people who really do believe in homeopathy and so on. some of the people who peddle this stuff really do believe it and have the best of intentions. but there are some very cynical, mercenary people who are driven entirely by selfish reasons to exploit vulnerable people when they are sick. but perhaps, as ernst suggests here, there’s a third group – people who convince themselves and make a nice living at the same time. overall this is certainly an interesting read – with plenty of useful information with which to counter fraudsters and fakes. there’s even a section on how to set yourself up as a charlatan – yep, you too can claim to cure cancer, fight dementia and tackle bad breath. posted by pan pantziarka at 08:31 0 comments email this blogthis! share to twitter share to facebook share to pinterest labels: books , scam tuesday, 20 march 2018 wisdom of crowds ‘the wisdom of crowds’ is the name of a book by james surowiecki in which he discusses the idea that in certain situations aggregating the knowledge from a random crowd of people could get to a better answer to a problem than any single individual could – even an expert individual. it wasn’t a new idea – according to wikipedia (never a reliable source, so not a good ‘crowd’ example) that in 1907 francis galton noted that a crowd at a county fair correctly guessed the weight of an ox when you took the average of all the guesses. surowiecki’s book certainly popularised the term – i even used it in the title of a paper on drug repurposing: ‘ the wisdom of crowds and the repurposing of artesunate as an drug ’ – and it has become something of a standard feature of many books and courses in machine learning and data science. the nobel prize-winning economist and political scientist frederich von hayek didn’t, as far as i know, use the term but the idea was central to his thinking. he saw the price/market system as the wisdom of the crowds in action. he saw the society as a complex and self-organised system, with distributed decision making and dispersed knowledge as they key driving forces. trying to control an economy from the top down is impossible without access to all that knowledge - knowledge that we are often not even explicitly aware that we have. i’ve often wondered though whether it really works in practice, or was it really the case that yet again the world is far too complex and messy for even this simple (and surprising) idea to work. at the weekend i finally managed to see a real world example. in the context of some fundraising for the george pantziarka tp53 trust (the uk charity that supports people with li fraumeni syndrome), we attended the modern equivalent of galton’s county fair – a suburban farmer’s market in south-west london. we didn’t have an ox to spare, so in our case the crowd had to correctly guess the number of chocolate easter eggs to win the prize (see below, we’ll skate over the health effects of eating all of those eggs…). this was my chance to get my hands on a real world data set. unfortunately the weekend coincided with a blizzard, so turn-out was low at the market and i was worried that the dataset wouldn’t be sufficient to show the effect. in the end we had 66 entries – and the correct answer was 145 eggs. the answers were all over the place, with a low of 50 and a maximum of 376 (see scatter chart below – correct answer in red). the lucky winner got close with an answer of 143. so how wise was our crowd of 66? the average of the entire data set was 144.1 – which is closer than the winning entry. i have to admit i was surprised at just how close that is. even more surprising is how quickly the average converged to the correct answer. the chart below shows the cumulative moving average converging close to the right answer within 15 guesses. that’s fast. was that speed of convergence just a fluke? when the dataset is reversed what happens? the same thing – the cumulative moving average gets close to the correct average incredibly quickly, even though it starts off with some wildcard answers. although this idea might be old hat – i for one am still impressed at these results. although the applications for this idea are limited – it would be great to be able to harness this sort of thing to solve something a bit more meaningful than the size of an ox or the number of chocolate eggs. i also find the democratic nature of this result incredibly satisfying. posted by pan pantziarka at 08:15 0 comments email this blogthis! share to twitter share to facebook share to pinterest labels: models , tp53 wednesday, 26 april 2017 myc, models and tumour growth when i wrote the neatg model of tumour growth, published in the journal peerj ( https://peerj.com/articles/2176/ ), i focused on the behaviour of individual cells and on the role of cell competition and cell death in tumour growth. all models have to simplify and abstract, and the neatg model does exactly that. the model steered clear of the molecular basis for the behaviour of the cells – my working assumption was that cells produce soluble factors and signalling proteins that mediate their cell-cell and cell-tissue interactions. it was one of the reasons i called the model neatg ( non-physiological evolutionary algorithm for tumour growth – though as sebastien benzekry pointed out to me, the fact that the model has cells and tissues already makes it fairly physiological… ). despite the level of abstraction, the model clearly does show cellular behaviours that mimic aspects of tumour growth and response to cytotoxic chemotherapy. a surprise for me was that the model showed that accelerated tumour regrowth following chemotherapy is driven by cell competition and the levels of cell death. i spent time looking at the research literature on the

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anticancer.org.uk

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Nominet was able to match the registrant's name and address against a 3rd party data source on 10-Dec-2012

Registrar:
ICUK Computing Services Ltd [Tag = ICUK]
URL: http://www.icuk.net

Relevant dates:
Registered on: 21-Dec-2008
Expiry date: 21-Dec-2018
Last updated: 29-Jan-2017

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Registered until expiry date.

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ns1.interdns.co.uk 83.170.124.44
ns2.interdns.co.uk 83.170.124.7

WHOIS lookup made at 05:39:16 08-Jul-2018

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  ARGS anticancer.org.uk

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  TYPE domain

DOMAIN

SPONSOR
ICUK Computing Services Ltd [Tag = ICUK]
URL: http://www.icuk.net
Relevant dates:

  CREATED 21-Dec-2008

  CHANGED 29-Jan-2017

STATUS
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  NAME anticancer.org.uk

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Copyright Nominet UK 1996 - 2018.
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